Slam dunk yes for me.
I've never subscribed to the theory that The Canon needs to be strictly populated by the greatest films of all time or even the best films of specific genres. To me The Canon is and has always been a grouping of the most important pieces of cinema. They can be culturally significant, highly influential, groundbreaking and yes, even the best worst movie. This is why I voted yes for Star Wars, Jurassic Park, Cannibal Holocaust, Top Gun and now The Room.
Wiseau's accidental masterpiece will be discussed, analyzed, mocked and celebrated for years to come and that's certainly not the case for many films currently in The Canon.