Is it factual that The Apple Sisters do in fact have an overwhelming case of aids? If so will this come up in future episodes and how will it be worked into the ongoing story line? I think it would be the type of episode that gets a dialogue going, and it could feature appearances by President Roosevelt explaining to the listener that things can in fact get worse.
Also, do any of the sisters have a desire to date an overweight Shaloin "master" who has gained nominal notoriety off his friend's success? If so there's a slightly older gentleman in Venice California who can help with that, and the whole Aids thing.
