I just got my hands on all the 4th edition books and I've been desperately trying get my friends together for a group, but people are so busy and so cool that they're not into it.
Heck, the reason I listen to nerd poker is so I can get my D&D fix, so sign me up!
I've got some experience with Roll20 and Fantasy grounds2, and I've been knocking around some campaign ideas I'd really like to try, so I could DM if nobody else is interested.