I can't believe I'd forgotten about this, but when they brought up Rocko's Modern Life, it reminded me of this scene in one of the early episodes where Mrs. Bighead straight up tries to date rape Rocko.
I don't remember it exactly, but I think Mrs. Bighead is being neglected by Mr. Bighead, so she gets Rocko to come over and help around the house. She offers to make him a drink, goes over to a spice rack and they play out a visual gag panning across jars labeled something like "German Fly" (flies in lederhosen), "French Fly" (flies in striped shirt/berets), obviously building up to the jar labeled "Spanish Fly", which was an old slang term for roofies. I don't think he actually ends up drinking it, but I swear that happened in an episode.
Am I crazy, does anyone else remember this?