You guys touched on some really interesting stuff when you started talking about free will and genetic determinism, I think it was David who mentioned the idea that life is just a huge equation playing itself out, which is a good way of putting it, however I would've liked to see you guys explore that stuff more. Fate in the supernatural sense is not interesting to me because it seems so patently absurd, especially, as you guys talked about, when you look at the "fates" of the less fortunate and impoverished, but fate in the sense of determinism is extremely interesting and you can make a much more compelling argument for it. I'd like to see you guys do a full episode on free will, it may seem obvious that free will exists just by the intuitive feeling you have that you are controlling your actions, but the more you analyze it, the harder it becomes to rationalize, while at the same time, a world in which free will does not exist doesn't make much sense either.
Also, I don't know if Nick Kroll knows this, but his idea about how the poor/unfortunate need religion is pretty much a paraphrasing of Nietzsche's theory of how religion and morality in general originated. His idea was that in the early days of civilization, there were civilizations that didn't have enough resources and so had to conquer other civilizations, and then there were the peaceful, balanced civilizations that got conquered. The conquered peoples had to rationalize the atrocities committed upon them, so they came up with the idea of good and evil, and labeled themselves as the righteous ones, and this developed into ideas about eternal rewards for those who were good"= and punishments for those who were evil, and eventually it turned into religion.