Having worked in journalism, the difference between Wiseau and Breen really highlights the difference between what we called kooks and cranks.
Especially working in science journalism, my colleagues and I would get hundreds of emails, letters, phone calls, DVDs, fully bound manuscripts, etc., from people who had made shocking discoveries that were poised to turn the world upside down if they could only get the word out. Like Wiseau and Breen, these men (and they were 99.9% men) all had an incredibly high opinion of their own intelligence and importance, coupled with a sub-amateur-level grasp of their subject matter of choice.
Kooks, like Wiseau, have eccentric, disconnected-from-reality ideas, but also have a childlike enthusiasm for exploring them.
Cranks, like Breen, are at war. Even if they aren't explicitly alleging a global conspiracy to suppress their findings and ideas, they are on a mission and need to know whether you're going to help them or stand in your way. Cranks are the ones that will actually show up at your office and ask why you haven't been returning their calls.
That's why June's line about women being harmed in the making of this movie rang so true to me. The sex scenes in The Room were also gross and self-serving, but there is a sinister aspect to Breen that I just don't pick up from Wiseau.